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The Office of the U.S. Global AIDS Coordinator (S/GAC), U.S. Department of State, is responsible for implementing the President's Emergency Plan for AIDS Relief (PEPFAR) – the U.S. Government initiative to support partner nations around the world in responding to HIV/AIDS. PEPFAR was launched in 2003, and is the largest commitment by any nation to combat a single disease internationally in history. Through PEPFAR, the U.S. Government has committed approximately $32 billion to bilateral HIV/AIDS programs; the Global Fund to Fight HIV/AIDS, Tuberculosis and Malaria; and bilateral tuberculosis programs through Fiscal Year (FY) 2010. The human impact of America's investments in partner nations' efforts is profound. PEPFAR has directly supported life-saving antiretroviral treatment for over 2.4 million men, women and children as of September 2009. PEPFAR has directly supported more than 11 million people with care and support programs, including more than 4 million orphans and vulnerable children, through FY 2009. PEPFAR's efforts around prevention of mother-to-child transmission programs have allowed nearly 340,000 babies of HIV-positive mothers to be born HIV-free, including nearly 100,000 in FY 2009. PEPFAR is the cornerstone and largest component of the President's Global Health Initiative. This Initiative supports partner countries in improving health outcomes through strengthened health systems, with a particular focus on improving the health of women, newborns and children through programs that address a range of health issues.