SATB2 Gene Foundation

The SATB2 Gene Foundation was established to enrich the lives of individuals with SATB2-Associated Syndrome, including those diagnosed with the condition and their families, through support, research and education.

Our mission will be met by:

• Providing support to families
• Supporting research in a wide range of issues related to SATB2-Associated Syndrome
• Raising awareness about the characteristics of SATB2-Associated Syndrome

SATB2-associated syndrome (aka Glass Syndrome) is caused by problems in the SATB2 gene located on chromosome 2q33.1, which is a neurodevelopmental disorder. SAS affects the individuals through global developmental delays. Most significant is the absence of speech, or significantly delayed/affected speech. We often see palate abnormalities – including cleft palate or high arched palate. Other key characteristics of SAS are dental issues – missing adult teeth and/or oversized front teeth; low bone density, and behavioral issues. We are seeing a growing number of our patients with seizures and sleep difficulties.