The Rita Allen Foundation invests in ideas in their earliest stages, promoting breakthrough solutions to significant problems in science and society. Established in 1953, it has provided major grants to more than 100 biomedical scholars, many of whom have made important advances with their research. Since 2009, the Foundation’s resources and areas of investment have expanded. It now uses strategic philanthropy to promote civic literacy and engagement as well as support young leaders in the sciences and social innovation.